Downregulation of S100 calcium binding protein A12 inhibits the growth of glioma cells
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Downregulation of Kinesin Spindle Protein Inhibits Proliferation, Induces Apoptosis and Increases Chemosensitivity in Hepatocellular Carcinoma Cells
Background: Kinesin spindle protein (KSP) plays a critical role in mitosis. Inhibition of KSP function leads to cell cycle arrest at mitosis and ultimately to cell death. The aim of this study was to suppress KSP expression by specific small-interfering RNA (siRNA) in Hep3B cells and evaluate its anti-tumor activity. Methods: Three siRNA targeting KSP (KSP-siRNA #1-3) and one mismatched-siRNA (...
متن کاملCalcium-binding S100 protein expression in pterygium
PURPOSE Pterygium is an ocular surface disease of unknown etiology associated with epithelial and fibrovascular outgrowth from the conjunctiva onto the cornea. S100 proteins are calcium-activated signaling proteins that interact with other proteins to modulate biological functions such as cell migration, proliferation, and differentiation. The aim of this study was to investigate the presence o...
متن کاملS100A9 (S100 calcium binding protein A9)
Note S100A9 belongs to the S100/calgranulin family of small non-ubiquitous cytoplasmic Ca-binding proteins of EF-hand type. The proteins were referred to "S100" because of their solubility in saturated ammonium sulphate solution. Sixteen of 21 members are localised in a cluster on human chromosome 1q21. The clustered organization of these S100 genes is conserved during evolution (Ridinger et al...
متن کاملDownregulation of S100 Calcium Binding Protein A9 in Esophageal Squamous Cell Carcinoma
The development of esophageal squamous cell carcinoma (ESCC) is poorly understood and the major regulatory molecules involved in the process of tumorigenesis have not yet been identified. We had previously employed a quantitative proteomic approach to identify differentially expressed proteins in ESCC tumors. A total of 238 differentially expressed proteins were identified in that study includi...
متن کاملBinding of pEL98 protein, an S100-related calcium-binding protein, to nonmuscle tropomyosin
The cDNA coding for mouse fibroblast tropomyosin isoform 2 (TM2) was placed into a bacterial expression vector to produce a fusion protein containing glutathione-S-transferase (GST) and TM2 (GST/TM2). Glutathione-Sepharose beads bearing GST/TM2 were incubated with [35S]methionine-labeled NIH 3T3 cell extracts and the materials bound to the fusion proteins were analyzed to identify proteins that...
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ژورنال
عنوان ژورنال: BMC Cancer
سال: 2020
ISSN: 1471-2407
DOI: 10.1186/s12885-020-06768-7